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The immunoassay detected the 14-3-3 protein in cerebrospinal fluid from y8 of the 71 patients with Creutzfeldt-Jakob disease(96 percent;95 percent confidence interval,92 to 99 percent).Among 94 patients with other dementias,the specificity was 96 percent.If one excludes the three patients with dementia who had strokes within one month before testing,the specificity was 99 percent.The test was positive in 12 or 24 patients with viral encephalitis.In animals the sensitivity of the assay was 87 percent and the specificity was 99 percent.In patients with dementia,a positive immunoassay for the 14-3-3 brain protein in cerebrospinal fluid strongly supports a diagnosis of Creutzfeld-Jakob disease.This finding,however,does not support the use of the test in patients without clinically evident dementia. |
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advances in neurology
bovine spongiform encephalopathy
cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,protein of
dementia
dementia,rapidly progressive
dementia,transmissible
electrophoretic pattern,CSF
encephalopathy
Jakob-Creutzfeldt disease
neurologic disease,diagnoses of
prion disease
protein 14-3-3,cerebrospinal fluid
spongy degeneration of brain
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